ReviewFrontier dental research on iPS cells
Section snippets
Gingiva as an iPS cell source
Various tissue engineering technologies have been developed in recent years using stem cells as a source for missing tissues. Induced pluripotent stem (iPS) cells, which have similar potential to embryonic stem (ES) cells, can be generated through the reprogramming of somatic cells from different tissues by the forced expression of defined exogenous factors. These iPS cells can be efficiently generated from accessible tissues and have potential for use in various clinical applications [1].
The
Induction of ameloblast differentiation of iPS cells for tooth regeneration
Tooth development and morphogenesis are regulated by reciprocal interactions between oral epithelial cells and mesenchymal cells derived from the cranial neural crest. Oral epithelial cells differentiate into enamel-forming ameloblasts, whereas mesenchymal stem cells (MSCs) form dentin-forming odontoblasts. Recent studies of regenerative dentistry have revealed viable techniques to differentiate stem cells into odontoblasts, cementoblasts, and osteoblasts. However, the mechanism of ameloblast
Conflict of interest
The authors declare no conflict of interest.
Acknowledgment
This investigation was supported by Grants-in-Aid for Young Scientists (A: 22689049, H.E.) and for Scientific Research (B: 25293395, H.E.) from the Japan Society for the Promotion of Science, by the Iwate Medical University Open Research Project (K.O. 2007–2011), by a Grant-in-Aid for Scientific Research (No. 19562128, M. A.) and a Grant-in-Aid for Young Scientists (No. 20679006 M. A.) from MEXT, and by the Next Program LS010.
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Cited by (4)
Oral biosciences: The annual review 2013
2014, Journal of Oral BiosciencesApplication of stem cells in oral disease therapy: Progresses and perspectives
2017, Frontiers in PhysiologyiPS cells—the triumphs and tribulations
2016, Dentistry JournalRegenerated teeth: The future of tooth replacement. An update
2015, Regenerative Medicine
- 1
These authors contributed equally to this work.
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